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Clinical research has indicated that humor may have a direct effect on the body's ability to fight infections. According to the American Association for Therapeutic Humor, a St. Louis-based nonprofit group, laughter boosts the body's production of killer white blood cells that attack infectious agents in the body. "We now have proof that humor and laughter improve the chemicals in your body, in both the short and long terms," according to Karyn Buxman, a member of the organization and former nurse who writes and speaks on the subject of therapeutic humor.